De modo significativo (en. Significantly)

Translation into Spanish

However, in cases where the goods and services are significantly different from each other and such a connection between the respective publics is not obvious, the opponent must justify why the marks will be associated, by reference to some other link between its activities and those of the applicant, for example where the earlier mark is exploited outside its natural market sector, for instance, by licensing or merchandising (see paragraph 3.3 above).
Sin embargo, en los casos en que los productos o servicios difieran considerablemente entre sí y no resulte evidente la relación entre los públicos respectivos, el oponente deberá justificar la asociación entre las marcas, haciendo referencia a algún otro vínculo entre sus propias actividades y las del solicitante, como ocurre cuando la marca anterior se utiliza fuera de su sector de mercado natural a través, por ejemplo, de acuerdos de licencia o de comercialización (véase el punto 3.3 supra).
Example taken from data source: ELRC-EUIPO_2017_v1
Since then, his involvement has increased significantly.
Desde entonces, su participación ha aumentado considerablemente.
Example taken from data source: ELRC-1125-CORDIS_News_v1
NASA and ESA have been monitoring how the Nitrogen dioxide gases dropped significantly during the initial Chinese phase of the COVID-19 pandemic.
La NASA y la ESA han estado controlando cómo los gases de dióxido de nitrógeno cayeron significativamente durante la fase china inicial de la pandemia por COVID-19.
Example taken from data source: ELRC-wikipedia_health_v1
Content might differ significantly in different countries.
El contenido podría diferir significativamente en países diferentes.
Example taken from data source: wikimedia_v20210402
However, cardiovascular mortality is not significantly reduced.[2].
Sin embargo, la mortalidad cardiovascular no se reduce significativamente[2].
Example taken from data source: wikimedia_v20210402
SOLVIT has evolved significantly since its inception.
SOLVIT ha evolucionado considerablemente desde su creación.
Example taken from data source: DGT_v2019
However, these marks are significantly different to BRINFIX.
Sin embargo estas marcas son radicalmente distintas a BRINFIX.
Example taken from data source: ELRC-1076-EUIPO_law_v1